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Frequently asked questions

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Frequently asked questions

The list below includes questions frequently asked by existing Prolia® (denosumab) patients, or those being considered for Prolia® treatment. If you have any questions about your treatment programme, please discuss these with your doctor.

Prolia® is licensed for treating:

  • Osteoporosis in women after the menopause (postmenopausal) and men who have an increased risk of fracture (broken bones), reducing the risk of spinal, non-spinal and hip fractures.
  • Bone loss that results from a reduction in hormone (testosterone) level caused by surgery or treatment with medicines in patients with prostate cancer.

What do I need to remember?

  1. While being treated, you should maintain good oral hygiene and receive routine dental check-ups. If you wear dentures you should make sure these fit properly. If you are under dental treatment or will undergo dental surgery (e.g. tooth extractions), inform your doctor about your dental treatment and tell your dentist that you are being treated with Prolia®
  2. If your doctor has prescribed calcium and/or vitamin D it is important that you take this as instructed during your Prolia® treatment (until advised otherwise by your doctor).1
  3. If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in the package leaflet. You can also report side effects directly via the Yellow Card Scheme at www.mhra.gov.uk/yellowcard. By reporting side effects you can help provide more information on the safety of this medicine. Adverse events should also be reported to Amgen Limited on +44 (0) 1223 436441
  4. Check that you have been booked in for future injections. The benefits of Prolia® start from the first injection but because the treatment effect does wear off, if you miss an injection you might increase your risk of fracture.

For complete information on what you need to know before you use Prolia® please see the Considerations before starting Prolia page or the PIL.

Both calcium and vitamin D play a vital role in maintaining strong bones. Calcium supplements ensure your body has the right level of calcium for different functions in your body and vitamin D helps ensure that the calcium you take (through supplements or through your diet) is transferred into the bloodstream.

Prolia® may lower the calcium levels in your blood. If you have low blood calcium, it may get worse during treatment, so your low blood calcium must be treated before you receive Prolia®.1

You can get calcium from dairy products such as milk and cheese and you can boost your vitamin D levels through exposure to sunlight. Your doctor will prescribe supplements to increase your calcium and vitamin D.

For more information on what you can do to build healthy bones, please visit the National Osteoporosis Society website.

The amount of calcium and vitamin D you need will depend on your levels to start with, so will be specific to you. Your doctor can measure these levels through single blood tests and will then decide on the correct dose of supplements, and may advise you on maintaining or increasing your levels through lifestyle changes such as diet and exposure to sunlight.

Simply book in for an injection as soon as it is convenient for you and your doctor. The treatment effect of Prolia® does wear off if treatment is stopped, so it is important you continue to get your injection every six months. If you miss an injection you might increase your risk of a fracture.

Yes. The manufacturers of Prolia® have provided a support programme. Speak to your doctor or nurse about the reminder service that is offered.

Also, many areas in the UK have developed their own systems for supporting patients so talk to your local doctor for tips on remembering when your next injection is due.

After you have received your first Prolia® injection in the hospital, your care may be handed back to your GP surgery. Also, as it is a single under-the-skin (subcutaneous) injection given every six months, this allows any healthcare professional trained in administering injections to give you the injection e.g. your local nurse or even your local pharmacist in some areas.

For more information on what support services are available, please visit the National Osteoporosis Society website.

References
  1. Prolia® (denosumab) Patient Information Leaflet